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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 22nd September 2025 Vol. No. 14 ; Issue No.701
Publications

1. Iengar P, Venkatraman P (2025). Using the reactome graph database to generate pathway fingerprints for cancer-related genes, and using the fingerprints to gain insights into cancer, comorbidity, and cancer gene networks. Computational Biology and Chemistry.

2. Jalali R, Ghosh S, Chatterjee A, Goswami S, Shah N, Dutta D, Krishna U, Gupta T, Goda JS (2025). High-precision radiotherapy achieves excellent long-term control and preserves function in pediatric craniopharyngioma-Subset analysis of a randomized trial. Neuro Oncology.

Book/Manual
Samantaray S, Patil S, Patra P, Mohanty S, Swain S, Panda P, Budukh A, Chaturvedi P (2025). Identification and management of oral potentially malignant disorders and cancer: Manual for health workers of Odisha state. Tata Memorial Centre, Mumbai. (ISBN: 978-93-82963-79-0)

Site of the Week

ChEMBL is a manually curated database of bioactive molecules with drug-like properties. It brings together chemical, bioactivity and genomic data to aid the translation of genomic information into effective new drugs.

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Interesting Reads

Hegde S, Giotti B, Soong BY, Halasz L, Le Berichel J, Schaefer MM, Kloeckner B, Mattiuz R, Park MD, Magen A, Marks A, Belabed M, Hamon P, Chin T, Troncoso L, Lee JJ, Fan K, Ahimovic D, Bale MJ, Nie K, Chung G, D'souza D, Angeliadis K, Kim-Schulze S, Flores RM, Kaufman AJ, Ginhoux F, Buenrostro JD, Josefowicz SZ, Tsankov AM, Marron TU, Ma S, Brown BD, Merad M (2025). Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours. Nature.

Video of the Week
The origins of Cancer
Upcoming Events
21st Annual Live Surgical Oncology Workshop

November 20-222, 2025

At ACTREC, Tata Memorial Centre, Kharghar

14th In Vivo Preclinical Imaging and Drug Discovery Hands-on Workshop

November 12-14, 2025

At ACTREC, Tata Memorial Centre, Kharghar

Anaesthesia Review Course 2025

October 1-2, 2025

At ACTREC, Tata Memorial Centre, Kharghar

Do You Know?

In 2014, Pembrolizumab (Keytruda) became the first PD-1-targeting immune checkpoint inhibitor approved by FDA.

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Cancer News
Scientists identify dual protein targets to weaken pancreatic cancer defenses.

MedicalXpress, 18/09/2025

The scientists used a drug they developed called APX2014 to block Ref-1 in addition to removing PRDX1. Without the function of both proteins, tumors significantly shrank and more cancer cells died...

Rogue DNA rings may be the secret spark driving deadly brain cancer

Sciencedaily, 17/09/2025

Rogue DNA rings known as ecDNA may hold the key to cracking glioblastoma’s deadly resilience. Emerging before tumors even form, they could offer scientists a crucial early-warning system and a chance to intervene before the disease becomes untreatable...

Glioblastoma cells “unstick” from their neighbors to become more deadly

EurekAlert, 18/09/2025

The study offers a new possible explanation for why the cancer is so difficult to treat. The researchers found that “dispersed” cells in the tumor are more plastic, a biological term for cells that are malleable and able to shift to different forms or states...

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